1. 檢驗醫學部基因診斷實驗室於2018.03.08起，更換檢驗項目「EGFR exon 18,19,20,21突變分析」FFPE檢體(院內碼: 3014434)之檢驗試劑，新增之可偵測突變位點及相關資訊如下表：
原試劑
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新試劑
| |
廠牌名稱
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EGFR RGQ PCR kit (Qiagen)
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Cobas EGFR Mutation Test V2 (Roche)
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偵測位點
(底線粗體為異動部分)
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Exon 18: G719X
Exon 19: 19 types of exon 19 deletion
Exon 20: T790M, S768I and 3 types of exon 20 insertion
Exon 21: L858R, L861Q
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Exon 18: G719X
Exon 19: 29 types of exon 19 deletion
Exon 20: T790M, S768I and 20 types of exon 20 insertion
Exon 21: L858R, L861Q
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2. 臨床用藥參考 (S: sensitive, R: resistant, NA:尚無實證確認資料)：
Exon 18
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Exon 19
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Exon 20
|
Exon 21
| ||||
G719X
|
insertions
|
insertions
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S768I
|
T790M
|
L858R
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L861Q
| |
Iressa (Gefitinib)
|
S
|
S
|
R
|
R
|
R
|
S
|
S
|
Tarceva (Erlotinib)
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S
|
S
|
R
|
R
|
R
|
S
|
S
|
Giotrif (Afatinib)
|
S
|
S
|
R
|
R
|
R
|
S
|
S
|
Tagrisso (Osimertinib)
|
NA
|
NA
|
NA
|
NA
|
S
|
NA
|
NA
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3. 相關收檢方式及檢驗流程不變，若有疑問請來電基因診斷實驗室詢問(分機: 7260)